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Tag: longevity

Via Grinding

One of the most famous tales in all of Chinese medicine is that of a master herbalist, healer and mountain man known as Li Ching-Yuen. His death in 1933 was reported in newspapers across the world, including obituaries that ran in both Time magazine and the New York Times. He was said to have buried 23 wives and had been living with his 24th, a woman of 60, and had 180 descendants stretching back eleven generations. The fingernails of his venerable right hand were six inches long, yet he appeared to be man somewhere in his 60’s. A posthumous account written three years after his death by Chinese General Yang Sen entitled “A Factual Account of the 250 Year-Old Good-Luck Man.”, described him as having stood seven feet tall with good eyesight, a brisk stride and a ruddy complexion. Li Ching-Yuen was 256 years old.

Imperial records indicate Li Chung Yun was born in 1677 in Chyi Jiang Hsie, Szechuan province. He spent most of his life in the mountain ranges gathering herbs and knowledge of longevity methods. In 1748, when he was 71 years old, he moved to Kai Hsien to join the Chinese army as teacher of the martial arts and as a tactical advisor. Records state that the Imperial Chinese government congratulated him both on his 150thth birthdays. Correspondents from the New York Times in 1928 reported that the oldest residents in Szechuan claimed that their grandfathers had known him when they were children, and looked much the same as he had upon his death.


By analyzing just 150 spots on the genome, researchers can predict who will live to extreme old age with almost 80 percent accuracy, according to a study published online today in the journal Science. Researchers from Boston University employed a widely used genetic-screening technology to find genetic variations that occur more frequently in centenarians–people age 100 and older.
In addition to providing a potential way to predict who might live into their 100s, the findings suggest that genetics play a major role in surviving to extreme old age. And the team hopes that identifying the genes and corresponding molecular mechanisms that promote longevity will give new insight into how to prevent or delay age-related diseases, such as heart disease, Alzheimer’s, and cancer.

“Centenarians are a model of aging well,” says Thomas Perls, director of the New England Centenarian Study at Boston Medical Center and an author of the study. Previous findings from the project, the largest study of centenarians in the world, show that 90 percent of them are free of disability to an average age of 93. “They seem to compress disability to the end of their lives,” says Perls. “I am very hopeful that understanding how centenarians do that will lead to new strategies for therapies.”

Perhaps most surprisingly, preliminary analysis showed that centenarians had just as many genetic variants linked to diseases as did people in the control group. “That suggests that what makes people live long lives is not lack of genetic disposition to disease but longevity-promoting genes,” says Paola Sebastiani, a biostatistician at Boston University and coauthor of the study. “If longevity variants cancel out disease-associated variants, it could open new ways of treating age-related diseases.”