By emulating nature’s design principles, a team at Harvard’s Wyss Institute for Biologically Inspired Engineering, Harvard Medical School and Dana-Farber Cancer Institute has created nanodevices made of DNA that self-assemble and can be programmed to move and change shape on demand. In contrast to existing nanotechnologies, these programmable nanodevices are highly suitable for medical applications because DNA is both biocompatible and biodegradable.
“This new self-assembly based nanofabrication technology could lead to nanoscale medical devices and drug delivery systems, such as virus mimics that introduce drugs directly into diseased cells,” said co-investigator and Wyss Institute director Don Ingber. A nanodevice that can spring open in response to a chemical or mechanical signal could ensure that drugs not only arrive at the intended target but are also released when and where desired.
“These little Swiss Army knives can help us make all kinds of things that could be useful for advanced drug delivery and regenerative medicine,” said lead investigator William Shih, Wyss core faculty member and associate professor of biological chemistry and molecular pharmacology at HMS and Dana-Farber Cancer Institute. “We also have a handy biological DNA Xerox machine that nature evolved for us,” making these devices easy to manufacture.
